Abstract
Oral verrucous carcinoma (VC) is a variant of the squamous cell carcinoma (SCC) characterized by exophytic appearance, locally destructive growth, but no metastasis tendency. However, “hybrid” lesions comprised of typical VC associated with foci of invasive SCC have been reported. In this study, is reported a case of a78-year-old white male patient presenting a verrucous leukoblast lesion, with 40 mm diameter, asymptomatic, in the mouth floor, with 2 months evolution. Incisional biopsy revealed intense epithelial proliferation forming high exophytic hyperkeratinized and “keratin plugs”. In focal areas, formation of epithelial nests exhibiting cytologic atypia invading the connective tissue was noted. Tumor cells exhibited intense positivity for p16, but weak for Ki-67. The diagnosis was VC with focal invasive SCC. In this case, is provided a discussion of the parameters of differential diagnosis with other verrucous lesions of the oral cavity, as well as the clinical significance of the invasive areas.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
