Abstract
Background: Although, anthracyclines are efficacious in pediatric cancers, their utilityis limited by progressive cardiotoxicity. Ventricular arterial coupling (VAC), a ratio of left ventricle (LV) elastance and arterial system afterload, relates to outcomes in heart failure in adults. An optimal relationship between the arterial afterload and LV elastance is required for LV efficiency. However, data on the role of VAC in children following chemotherapy is lacking. We hypothesized that VAC will be abnormal in children even many years following completion of anthracycline chemotherapy compared to normal population. Objective: To …
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