Abstract
Evaluation of: Woods AK, Hoffmann DS, Weydert CJ et al. Adenoviral delivery of VEGF121 early in pregnancy prevents spontaneous development of preeclampsia in BPH/5 mice. Hypertension 57(1), 94–102 (2011).Preeclampsia is a pregnancy-specific hypertension characterized by proteinuria and maternal endothelial dysfunction. Recent research has focused on the balance of pro- and anti-angiogenic factors in the development of the disorder, specifically the proteins VEGF, PlGF, sFlt-1 and sEng. In a recent paper, Woods et al. demonstrated that administration of adenovirally delivered VEGF attenuates the pathological features of preeclampsia that are present in a novel murine model of the disorder, the BPH/5 mouse. This is a recent addition to a body of literature that suggests an important role for VEGF bioavailability in the maintenance of a healthy endothelium during pregnancy, and suggests an intriguing target for the development of new therapeutics for the treatment of preeclampsia.
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