Abstract
Many investigators have noted increased pressor (or diminished depressor) substances in the blood of patients with hypertension.1-4 Others frequently employing similar methods, have failed to find them.5-9 We have used the denervated rabbit's ear preparation as described by Pissemski10 and modified by Katz11 to compare the effect of blood of persons with hypertension and subjects with normal blood pressures. This preparation has been found to be sensitive to known pressor substances in high dilutions (epinephrine 1 to 100,000,000 and pitressin 1 to 150,000), and has an important advantage in that whole undiluted relatively unchanged blood plasma may be used. In the early experiments the inflow pipette was connected to a Mariotte bottle. Subsequently we found a constant volume pump to be more satisfactory.The perfusion was started with Tyrode's solution and followed with unheated plasma alternating between blood from normal and hypersensitive individuals and noting the changes in pressure with constant inf...
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