Abstract
We investigated the association of HLA on clinical outcomes in our cohort of patients in the haplo-HSCT program using the HLAMatchmaker (EM) and PIRCHE score (PS) algorithms. The group comprised 64 patients (male=35-54.7%, female 29-45.3%; median age 43years) and their related haplo-HSCT donors (male=30-46.9%, female 34-53.1%). HLA-A/B/C/DRB1/DQB1/DPB1loci were analyzed. Multivariate analysis of the association between different HLA or patient/donor-related parameters and clinical outcome revealed the following associations with statistical significance: GvHD and HLA class I PS in the GvH direction (p=.0420) and relapse with diagnosis (p=.0163). For OS, the only variable showing a tendency of association was the source of HSCT (p=.0965). Combined results of univariate and multivariate analysis suggest that the patients awaiting the selection of the best haplo-HSCT donor could benefit the most from the combination of all three approaches, in cases when a suitable donor can be chosen from a number of potential donors.
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