Abstract
Key Points in a previous article ([1][1]), we discussed variation between individuals, termed variance. When measurements are taken of subjects in separate groups, the variance of the measurements within the group can be compared with the variance that exists between groups. This allows us to
Highlights
Fixed factors can reduce variation Replicates are repeated measurements from within an experimental unit Replication means that samples can no longer be considered random Comparisons of replicated values require correction, usually by reducing the effect of sample size Correction requires knowledge of the intra-class correlation
This article is covered by a non-exclusive license between the authors and the Nutrition Society (London, UK) and is being simultaneously published in 2011 in The Journal of Physiology, Experimental Physiology, British Journal of Pharmacology, Advances in Physiology Education, Microcirculation, and Clinical and Experimental Pharmacology and Physiology as part of a collaborative initiative among the societies that represent these journals
It might be that we only catch the ones that can’t jump too far, or those that jump towards a flashlight, or those that are awake, or sexually active . . . There are lots of reasons, but we must recognize that a potential fixed factor is at play, which could affect the measurements
Summary
Drummond[1] and Sarah L. Vowler2 1Department of Anaesthesia and Pain Medicine, University of Edinburgh, Royal Infirmary, Edinburgh; and 2Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, United Kingdom
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