Gene | VOL. 823
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Variation in caprine KRTAP1-3 and its association with cashmere fibre diameter.

Publication Date May 20, 2022

Abstract

Keratin-associated proteins (KAPs) are components of cashmere fibres. The gene encoding the KAP1-3 protein (KRTAP1-3) has been described in goats, but little is known about sequence variation in this gene and if it affects cashmere fibre traits. In this study, we used a polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP) technique to screen for nucleotide sequence variation in caprine KRTAP1-3 in 327 Longdong cashmere goats, then analysed association between the genetic variation that was revealed and some cashmere fibre traits. Six PCR-SSCP patterns representing six different variant sequences of KRTAP1-3 (named A to F) were revealed. Among these variant sequences, seven single nucleotide polymorphisms (SNPs) were detected, with two of them being non-synonymous. Goats with genotype AC had higher mean fibre diameter (MFD) than those with genotype AB (P<0.001), while goats with genotype AB had higher MFD than those with AA (P<0.001). The presence of C (P<0.001) and B (P=0.006) in a genotype was associated with increased MFD, and together this suggests that variation in caprine KRTAP1-3 affects the key fibre trait of MFD.

Concepts
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Mean Fibre Diameter
Cashmere Fibre
Seven Single Nucleotide Polymorphisms
Polymerase Chain Reaction-single Strand Conformation
Polymerase Chain Reaction-single Strand Conformation Polymorphism
Chain Reaction-single Strand Conformation Polymorphism
Genotype AB
Cashmere Fibre Diameter
Cashmere Traits
Keratin-associated Proteins

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