Abstract
A glycopcptidc antibiotic, ristocetin, induces platelet agglutination in the presence of von Wlllebrand factor (vWF), a part of Factor VIII complex (1) The role of ristocetin in the platelet agglutination has not yet been fully clarified. Recently, ristocctin was found to facilitate vWF binding to platelets in a concentration-dependent manner (2-6). Vancomycin, which is a structural analog of ristocetin, does not agglutinate as ristocatin does, but inhibits specificaliy ristocetin/vWF-induced platelet agglutination (7). As to the inhibltion mechanism of vancomycin, several researchers have proposed that vancomycin competes with ristocetin for binding to platelet membrane (8, 9). However, if vancomycin could interfere with the binding of vWF to platelets, then ristocetin/vWF-induced platelet agglutination might be inhibited. In the present study, we have examined the effect of vancomycin on the interaction of vWF with fixed and washed platelets in the absence or presence of ristocetln.
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