Abstract
A patient with a retroperitoneal mass extending into the liver had a core needle biopsy that showed a small, round, blue cell tumor of uncertain origin by light microscopy. The tumor cells stained with antibodies against vimentin, neuron specific enolase, and the S-100 protein. The cells did not stain with antibodies to muscle specific actin, chromogranin A, cytokeratin cocktail, or leukocyte common antigen. Based upon these histologic and immunohistochemical findings, consideration was given to either an extra-osseous Ewing's sarcoma or a peripheral neuroepithelioma, and a diagnosis of “consistent with peripheral neuroepithelioma” was rendered. The role of immunohistochemistry in resolving this differential and the resulting prognostic implications are discussed. (The J Histotechnol 20:67, 1997)
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