VALUE OF ECHOCARDIOGRAPHY AND CHEST CT IMAGING IN PATIENTS WITH HIGH-ALTITUDE PULMONARY HYPERTENSION

Abstract

SESSION TITLE: Late Breaking Pulmonary Vascular Disease PostersSESSION TYPE: Original Investigation PostersPRESENTED ON: 10/18/2022 01:30 pm - 02:30 pmPURPOSE: This study aimed to evaluate the value of echocardiography and chest computed tomography in patients with high altitude pulmonary hypertension.METHODS:Retrospective cohort studies were performed to compare echocardiographic and chest CT-related parameters in the HAPH group, the RHC-excluded PH group and the control population, and to detect their correlation with mPAP using Pearson analysis and Spearman analysis. Binary logistic regression analysis was performed to predict the diagnostic value of dPA, rPA, TR and their combination in the HAPH population. Receiver operating characteristic (ROC) curve analysis was used to identify the optimal SUV max cutoff value.RESULTS:A total of 89 cases in the clinically suspected HAPH population were included from January 2015 to January 2022. Correlation analysis showed that mPAP was positively correlated with TR and sPAP, and mPAP was positively correlated with dPA and rPA. In the control group, age was positively correlated with dAA. In the echocardiographic test, the most suitable TR cut-off value for differentiating HAPH from RHC-excluded PH was 3.21 (sensitivity 75.5%, specificity 80.6%, AUC = 0.834) according to ROC curve analysis; in the CT test, the most suitable dPA cut-off value was 34.41 (sensitivity 75.5%, specificity 83.3%, AUC = 0.831); the AUC for TR combined with dPA was 0.889, sensitivity and specificity 84.9% and 80.6%, respectively; in the CT assay, the best dPA cut-off value to distinguish HAPH from control according to ROC curve analysis was 29.82 mm ( sensitivity of 84.9%, specificity of 94.9%, AUC = 0.956); the optimal rPA cut-off value for distinguishing HAPH from controls was 0.95 (sensitivity of 88.7%, specificity of 88.1%, AUC = 0.942).CONCLUSIONS:We established optimal TR, dPA cut-off values and TR combined with dPA diagnostic efficacy for discriminating RHC-excluded PH patients from HAPH with a high degree of accuracy.CLINICAL IMPLICATIONS:Our study found a moderate correlation between mPAP and rPA, DPA and TR in a highland population with pulmonary hypertension. Chest CT and echocardiography can be used as primary screening methods for people with pulmonary hypertension, and the combination of the two leads to improved diagnostic outcomes.DISCLOSURES:No relevant relationships by Lu GuoNo relevant relationships by Yicen HanNo relevant relationships by xing he SESSION TITLE: Late Breaking Pulmonary Vascular Disease Posters SESSION TYPE: Original Investigation Posters PRESENTED ON: 10/18/2022 01:30 pm - 02:30 pm PURPOSE: This study aimed to evaluate the value of echocardiography and chest computed tomography in patients with high altitude pulmonary hypertension. METHODS: Retrospective cohort studies were performed to compare echocardiographic and chest CT-related parameters in the HAPH group, the RHC-excluded PH group and the control population, and to detect their correlation with mPAP using Pearson analysis and Spearman analysis. Binary logistic regression analysis was performed to predict the diagnostic value of dPA, rPA, TR and their combination in the HAPH population. Receiver operating characteristic (ROC) curve analysis was used to identify the optimal SUV max cutoff value. RESULTS: A total of 89 cases in the clinically suspected HAPH population were included from January 2015 to January 2022. Correlation analysis showed that mPAP was positively correlated with TR and sPAP, and mPAP was positively correlated with dPA and rPA. In the control group, age was positively correlated with dAA. In the echocardiographic test, the most suitable TR cut-off value for differentiating HAPH from RHC-excluded PH was 3.21 (sensitivity 75.5%, specificity 80.6%, AUC = 0.834) according to ROC curve analysis; in the CT test, the most suitable dPA cut-off value was 34.41 (sensitivity 75.5%, specificity 83.3%, AUC = 0.831); the AUC for TR combined with dPA was 0.889, sensitivity and specificity 84.9% and 80.6%, respectively; in the CT assay, the best dPA cut-off value to distinguish HAPH from control according to ROC curve analysis was 29.82 mm ( sensitivity of 84.9%, specificity of 94.9%, AUC = 0.956); the optimal rPA cut-off value for distinguishing HAPH from controls was 0.95 (sensitivity of 88.7%, specificity of 88.1%, AUC = 0.942). CONCLUSIONS: We established optimal TR, dPA cut-off values and TR combined with dPA diagnostic efficacy for discriminating RHC-excluded PH patients from HAPH with a high degree of accuracy. CLINICAL IMPLICATIONS: Our study found a moderate correlation between mPAP and rPA, DPA and TR in a highland population with pulmonary hypertension. Chest CT and echocardiography can be used as primary screening methods for people with pulmonary hypertension, and the combination of the two leads to improved diagnostic outcomes. DISCLOSURES: No relevant relationships by Lu Guo No relevant relationships by Yicen Han No relevant relationships by xing he