Abstract
1. 1. An evaluation of serum protein and immunoglobulins with regard to valproic acid (VPA) and phenytoin (phen) serum levels was performed in 28 epileptic patients. 2. 2. Serum antiepileptic levels were measured in fasting conditions. 3. 3. All patients were classified into the following groups: A (VPA below 50 μg/ml), B (VPA 50–89 μg/ml), C (VPA above 89 μg/ml), D (VPA 50–89 μg/ml and phen below 10 μg/ml). 4. 4. Patients of group C showed higher serum protein values than groups A ( P < 0.02), B and D ( P < 0.001). 5. 5. The α 2 and β-globulin fractions were higher in group C than the remaining groups ( P < 0.05). 6. 6. Immunoglobulin A, G and M remained unaltered in all patients.
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