Abstract

BackgroundThe usefulness of FDG PET/CT has been shown for staging and restaging of CRC patients. The purpose of this study was to determine the accuracy of 18F-FDG PET/CT in the detection of advanced colorectal adenomas in screening of high-risk asymptomatic individuals.ResultsA prospective study was conducted on 500 patients from January 2016 to June 2018 (300 male, 200 female) above 50 years of age (mean age 67.5 years) with +ve family history of CRC who underwent CTC. PET/CT was performed to all patients with +ve CTC findings.PET/CT sensitivity, specificity, positive predictive value, negative predictive value, and accuracy for all carcinomas and adenomas with high-grade dysplasia, per lesion, were 94%, 35%, 85%, 62%, and 66% respectively.PET/CT sensitivity, specificity, positive predictive value, negative predictive value, and accuracy for all carcinomas and adenomas with high-grade dysplasia, per patient, were 91%, 80%, 89%, 83%, and 86% respectively. Histopathology results were used as standard of reference.Conclusions18F-FDG-PET/CT is a promising tool in detecting advanced adenomas or carcinomas in high risk patients and it additionally enhance compliance with a screening program.

Highlights

  • The usefulness of FDG 18F-Fluorodeoxyglucose positron emission tomography/ computed tomography (PET/CT) has been shown for staging and restaging of Colorectal cancer (CRC) patients

  • Patients and methods A prospective study was conducted on 500 patients from January 2016 to June 2018 (300 male, 200 female) above 50 years of age with +ve family history of CRC who underwent Computed tomography colonography (CTC)

  • PET/CT was performed to all patients with +ve CTC findings

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Summary

Introduction

The usefulness of FDG PET/CT has been shown for staging and restaging of CRC patients. The purpose of this study was to determine the accuracy of 18F-FDG PET/CT in the detection of advanced colorectal adenomas in screening of high-risk asymptomatic individuals. Colorectal cancer is the third most diagnosed cancer in men, next to prostate and lung carcinoma. In women, it is the second most diagnosed cancer, next to breast cancer [1]. Studies have shown many risk factors which may increase the chance of developing CRC, as age above 50 years, individuals with positive family history of colorectal cancer [2].

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