Abstract
BackgroundHealth-Related Quality of Life (HRQoL) data together with clinical findings allow for monitoring of intervention efficacy and the effect on HRQoL. Children with Juvenile Idiopathic Arthritis (JIA) experience symptoms often persisting into adulthood, emphasising the need to track HRQoL.ObjectivesThe aim of this study was to investigate psychometric properties of the EuroQol five-dimensional youth questionnaire (EQ-5D-Y) in children with JIA.MethodsA cross-sectional, analytical study design was used. Children 8 to 15 years were recruited, completing the self-report EQ-5D-Y and two other HRQoL questionnaires. Known group validity was established by comparing the effect size between children with different disease severities. Concurrent validity was tested using Kruskal–Wallis to compare the ranking of scores on different questionnaires. Feasibility was assessed by number of missing responses and time to complete each questionnaire.ResultsAll questionnaires were able to distinguish between children with different JIA severity. There was a significant difference in ranking of most Juvenile Arthritis Multidimensional Assessment Report dimension scores across EQ-5D-Y levels, (p < 0.05), indicating concurrent validity. There was poor concurrent validity with the PedsQL dimensions tested with EQ-5D-Y, except for ‘pain’ (p = 0.001). The EQ-5D-Y was the quickest to complete with no missing values.ConclusionThis study showed that the EQ-5D-Y is valid and feasible in measuring HRQoL in JIA children and adequately responsive to detect change over time.Clinical implicationsIt is quick and easy to use in a busy clinical setting, allowing for effective JIA management monitoring.
Highlights
Health-Related Quality of Life (HRQoL) data together with clinical findings allow for monitoring of intervention efficacy and the effect on HRQoL
There was a significant difference in ranking of most Juvenile Arthritis Multidimensional Assessment Report dimension scores across EQ-5D-Y levels, (p < 0.05), indicating concurrent validity
The EQ-5D-Y was the quickest to complete with no missing values
Summary
Health-Related Quality of Life (HRQoL) data together with clinical findings allow for monitoring of intervention efficacy and the effect on HRQoL. Children with Juvenile Idiopathic Arthritis (JIA) experience symptoms often persisting into adulthood, emphasising the need to track HRQoL. Juvenile Idiopathic Arthritis (JIA) is an autoimmune, chronic rheumatic disorder with episodic flare-ups and remissions, occurring in children 16 years and younger, causing short- or long-term disability (Angeles-Han & Prahalad 2010). The pathophysiology of JIA includes the presence of autoantibodies or autoreactive T cells that initiate and perpetuate an inflammatory response, causing synovial inflammation and hypertrophy and joint effusion. This leads to chronic synovitis with eventual tissue damage and loss of joint function (Prakken, Albani & Martini 2011). Juvenile Idiopathic Arthritis is, still not a curable disease, and access to http://www.sajp.co.za
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