Abstract
In daily life, Artocarpus heterophylla Lamk., the leaves are rarely used even just as animal feed. In the bark of Artocarpus heterophylla Lamk there are new flavonoid compounds namely morusin, artokarpin, artonin E, cycloartobilosantone, and artonol B. This research is an experimental design with randomized posttest only with control group design. A total of 21 mice were divided into 3 groups, each consisting of 7 mice, group 1: negative control given oral placebo and exposed to UV-B rays, group 2:giving Vitamin C cream 4% mg and exposed to UV-B rays, group 3: giving cream of Artocarpus heterophylla Lamk leaf extract 4% and exposed to UV-B rays. The total of UV radiation dose of 600 mJ / cm² for 3 weeks, then performed a biopsy for examination of the amount of dermis collagen. The average number of collagen in the three groups after treatment was given significantly different (p <0.05). Mean and Significant level of collagen density of group 1 : 51,42 ± 5,16; group P2 ± 91,18 ± 1,13; and P3 group: 88,77 ± 1,10. Conclusion : Cream of 4% Artocarpus heterophylla Lamk leaf extract can increase the amount of collagen density in mice exposed to UV-B rays.
Highlights
UV light exposure in addition to providing beneficial effects to help the formation of vitamin D required by the bone, and has an adverse effect
The Artocarpus heterophylla Lamk leaf ethanol extract was prepared by using ethanol solvent, macerated with magnetic stirer until the sample sample was colorless and the filtrate was evaporated with a temperature evaporator of 40oC until a concentrated sample was obtained
The average number of collagen cells between the negative control group (P1) the positive control group (Vit C 4%) (P2) was significantly different with the p value = 0.000, indicating that there was a difference in collagen density between the negative control group and the administration of vitamin C
Summary
UV light exposure in addition to providing beneficial effects to help the formation of vitamin D required by the bone, and has an adverse effect. These effects depend on the intensity of the sun, the frequency of irradiation, the duration of irradiation, and the exposed surface area of sun exposure (Hadinoto et al, 2000). The effects of UV radiation on the dermis result in collagen degradation, collagen synthesis barriers, inflammation and oxidative stress, as well as decreased cell capability and eventually apoptosis. Various research has been done by experts to prove that the increase of UV-B radiation in the earth resulted in an increase in cases of skin cancer. According to Permenkes RI number 376 / menkes / per / VIII / 1990, sunscreen is a substance that can absorb at least 85% of sunlight
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