Abstract

Chest pain accounts for approximately 6% of all emergency department (ED) visits and is the most common reason for emergency hospital admission. One of the most serious diagnoses emergency physicians must consider is acute coronary syndrome (ACS). This is both common and serious, as ischemic heart disease remains the single biggest cause of death in the western world. The history and physical examination are cornerstones of our diagnostic approach in this patient group. Their importance is emphasized in guidelines, but there is little evidence to support their supposed association. The purpose of this article was to summarize the findings of recent investigations regarding the ability of various components of the history and physical examination to identify which patients presenting to the ED with chest pain require further investigation for possible ACS.Previous studies have consistently identified a number of factors that increase the probability of ACS. These include radiation of the pain, aggravation of the pain by exertion, vomiting, and diaphoresis. Traditional cardiac risk factors identified by the Framingham Heart Study are of limited diagnostic utility in the ED. Clinician gestalt has very low predictive ability, even in patients with a non-diagnostic electrocardiogram (ECG), and gestalt does not seem to be enhanced appreciably by clinical experience. The history and physical alone are unable to reduce a patient’s risk of ACS to a generally acceptable level (<1%).Ultimately, our review of the evidence clearly demonstrates that “atypical” symptoms cannot rule out ACS, while “typical” symptoms cannot rule it in. Therefore, if a patient has symptoms that are compatible with ACS and an alternative cause cannot be identified, clinicians must strongly consider the need for further investigation with ECG and troponin measurement.

Highlights

  • Ischemic heart disease remains the leading cause of death in the United States, accounting for a quarter of all deaths.[1,2] Accurate recognition of acute myocardial infarction (AMI) in the emergency department (ED) is crucial, as the mortality rate of patients with missed AMI is at least double that of similar patients who are accurately diagnosed.[3]

  • A recent retrospective analysis revealed that there was a very low incidence of short-term adverse cardiac events in chest pain patients who were hospitalized after an ED workup determined they were low risk.[10]

  • We review the evidence regarding the utility of the patient’s history and physical examination in determining the risk of acute coronary syndrome (ACS) in patients who present to EDs with chest pain

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Summary

Introduction

Ischemic heart disease remains the leading cause of death in the United States, accounting for a quarter of all deaths.[1,2] Accurate recognition of acute myocardial infarction (AMI) in the ED is crucial, as the mortality rate of patients with missed AMI is at least double that of similar patients who are accurately diagnosed.[3]. Chest pain is the second most common reason for ED visits, accounting for 5.4% of all presentations, and many of these patients are admitted for evaluation for ACS.[7] The costs involved are staggering: In the U.S in 2011, the cost for admitting patients with chest pain totaled $11.5 billion, representing 3% of the nation’s healthcare expenditures.[8] the mortality rate for admitted patients is lower than for those whose AMI goes undetected, hospital admission presents its own risks, including infection and procedural complications.[9] A recent retrospective analysis revealed that there was a very low incidence of short-term adverse cardiac events in chest pain patients who were hospitalized after an ED workup determined they were low risk (i.e,, patients with non-concerning vital signs, non-ischemic ECG, and two negative troponins taken in the ED between 60 and 420 minutes apart).[10] This finding suggests that not every patient with chest pain will benefit from a full admission and that risk stratification can be improved. We review the evidence regarding the utility of the patient’s history and physical examination in determining the risk of ACS in patients who present to EDs with chest pain

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