Abstract

BIOVITA 3 bacterial species (Clostridium butyricum, Lactobacillus sporogenes, and Bacillus subtilis) are spore forming probiotic bacteria that are blended as granules. Unlike lactic acid bacteria, which account for most of the available probiotics, the BIOVITA 3 bacterial species are easy to store and stably transit to the intestine, where they promote intestinal health owing to the unique features of the individual strains. The BIOVITA 3 bacterial species differ in their proliferation in different regions of the intestinal tract because of their differing oxygen demands. The aerobic Bacillus subtilis mainly proliferates in the upper small intestine, which has a high oxygen concentration. The facultative anaerobe Lactobacillus sporogenes proliferates well in the small intestine. The anaerobic Clostridium butyricum grows best in the large intestine, which has a relatively low oxygen concentration. In addition, each bacterial species displays positive effects on promoting the growth of bacteria resident in the lower intestine. The differential proliferation of the BIOVITA 3 bacterial species influences intestinal regulation throughout the intestine from the small to the large intestine. The species also improve intestinal regulation through mutual interactions that increase the growth of other beneficial bacteria.

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