Abstract
The aim was to determine plasma levels of sFlt-1 and sEng on the arterial and venous side of the uteroplacental circulation in preeclamptic patients and healthy controls.Preeclamptic patients had higher arterial concentrations than controls of sFlt-1 (17,450 vs 5055 pg/ml, p = 0.003) and sEng (68.7 vs 28.7 ng/ml, p = 0.003).In the preclampsia group sFlt-1 was higher in the uterine vein than in the radial artery (22,450 vs 17,450 pg/ml, p = 0.005). We found no gradient for sEng.Our results support the hypothesis that excess sFlt-1 at least partly originates in placenta, while excess sEng appears to have a different origin.
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