Abstract
1. 1. Oxytocin receptors in the uterus of the brushtail possum ( T. vulpecula) were characterized by radioreceptor assay and compared with those of the sheep and rat uterus. 2. 2. A single oxytocin binding site was found with an affinity ( K d) and receptor concentration ( Ro) of 3.0 ± 0.8 nmol/1 and 200 ± 60 fmol/mg protein, respectively (SEM; n = 5). The receptor was stable at −20°C; divalent ions were required for optimum binding. 3. 3. Competitive displacement curves with related peptides showed the following order of specificity: vasotocin > oxytoein > mesotocin = arginine-vasopressin = [Thr 4, Gly 7-oxytocin > lysine-vasopressin = isotocin >[ d( CH 2) 5, D- Phe 2, Ile 4, Ala 9- NH 2]- AVP. 4. 4. It was concluded that oxytocin receptors in the possum have similar characteristics to those of placental mammals.
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