Abstract

Objective To investigate the expression of USP22 and its potential targets in colorectal carcinoma. Methods 82 cases of colorectal carcinoma were examined by quantitative RT-PCR. Results Statistical correlation analysis in mRNA level shown that USP22 was strongly correlated with BMI-1(r=0.790, P<0.0001), c-Myc(r=0.528, P<0.0001)and cyclin D2(r=0.657, P<0.0001), but not correlated with p16INK4a(r=0.103, P=0.358)or p14ARF(r=-0.039, P=0.731). Conclusion USP22 may activate BMI1 oncogene-driven pathway signature such as INK4a/ARF or Akt signature via activating the c-Myc-targeted genes such as cyclinD2, which may act as important role in tumor progression. Key words: USP22; Colorectal cancer; Metastasis

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