Abstract
Methods for the enzyme-catalyzed resolution of a broad variety of fluorinated amino acids as well as for their incorporation into peptides and proteins using commercially available proteases have been developed. The synthetic strategies described here extend the scope of methods available for site-specific peptide and protein modification by fluorinated amino acids using simple and environmentally attractive routes. Moreover, a new screening system which has been developed for a systematic investigation of the molecular interactions of fluoro-substituted amino acids with native polypeptides is introduced.
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