Abstract

A wide range of single-molecule techniques has streamlined the process of applying and studying the effects of force on individual molecules. The Centrifuge Force Microscope (CFM) is one such technique that allows for high-throughput DNA pulling experiments in parallel. The technique is also relatively inexpensive and straightforward to use, making it a suitable tool for undergraduate research. A benchtop centrifuge can be used to apply centrifugal force to molecular constructs that are tethered between a glass slide and a microsphere.

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