Using temperature gradient gas chromatography to determine or predict vapor pressures and linear solvation energy relationship parameters of highly boiling organic compounds

Abstract

An isothermal chromatographic method allowing determination of ∑ β 2 H and ∑ α 2 H descriptors of the linear solvation energy relationship (LSER) was tested and results obtained are presented. This method is based on the use of four stationary phases of various polarity. On the other hand, it was demonstrated that the temperature gradient chromatography may be successfully used to determine LSER descriptors. Results of π 2 H, ∑ β 2 H and log L 16 determination are reported. This approach opens new possibilities of precise and rapid determination of LSER descriptors of high boiling compounds using a small number of phases. It was demonstrated that the log L 16 descriptor may be used to estimate vapor pressures of high boiling organic compounds with a better accuracy than those usually obtained with chromatographic methods.