Abstract
An aerobic oxidation operated in continuous flow is described as the key step in an efficient three-step route to AZD4635. By implementing this technique for the oxidation step, safety concerns in batch mode were addressed and an improved yield and quality of the product were obtained. Moreover, a PAT method (Fourier transform infrared (FTIR)) was employed to obtain a real-time analysis during the optimization in flow. The optimized three-step sequence was demonstrated on a multigram scale to give AZD4635 in 32% overall yield.
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