Abstract
Breast cancer is cancer that forms in the cells of the breasts. After skin cancer, breast cancer is the most common cancer diagnosed in women in the United States. Breast cancer can occur in both men and women, but it's far more common in women. Aim of this study to evaluate the lactate dehydrogenase and Gamma glutamyl transpeptidase as screening tests among women with breast cancer. Fifty women diagnosed with breast cancer were involved in this cross-sectional study, they were attended to Khartoum oncology hospital for diagnosis, treatment and follow up. They were grade I, II and III. Approval of study to be performed was obtained from each patient and hospital administration as well. Under hygienic condition blood withdrawn in plane containers from each subject considering labeling and data obtained from each one, blood allowed for clot formation and subsequent serum separation which preserved at -20 ℃ for later chemical analysis. Chemical analysis targeted enzymes, GGT, LDH and ALP, they measured by means of spectrophotometer method, using Biosystem device, reagents were Biosystem trademark, they were ready to use. This study conducted in concern of breast cancer, it involved 50 women with established diagnosis, the Mean±SD duration of the disease was (3.52+1.89) years and their age Mean±SD was (38.1+6.31) year’s .They were enrolled in the measurement of GGT and LDH Comparing the levels of measured parameters with normal value for each one, brought significant difference for LDH and ALP. Enzymes level among the three grades of breast cancer brought significant difference for LDH at grade II and III as p values 0.022 and 0.001 respectively, while GGT has only significant difference at grade III as p value 0.022. Significant elevation in serum levels of lactate dehydrogenase and Gamma glutamyl transpeptidase among patients with breast cancer and suggest that the estimation of both can be used as routine screening tests in all suspected carcinoma breast patients.
Highlights
Breast cancer is the second most frequently diagnosed malignancy just behind lung cancer, accounting for over two million cases each year
Under hygienic condition blood withdrawn in plane containers from each subject considering labeling and data obtained from each one, blood allowed for clot formation and subsequent serum separation which preserved at -20 °C for later chemical analysis
This study conducted in concern of breast cancer, it involved 50 women with established diagnosis, the Mean±SD duration of the disease was (3.52+1.89) years and their age Mean±SD was (38.1+6.31) years (Table -1)
Summary
Breast cancer is the second most frequently diagnosed malignancy just behind lung cancer, accounting for over two million cases each year. It is the leading cause of cancer death in women worldwide. Breast cancer deaths have decreased by one third or more over the past three decades. This is due in part to increased screening, as well as earlier and improved treatment for breast cancer. Detection and treatment of breast cancer improve survival because the breast tumor can be removed before it has a chance to spread (metastasize) [4]. Hormonal factors [7], reproductive factors, genetic factors, lifestyle, and dietary
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