Abstract
Human exposure to ionizing radiation induced overproduction of free radicals leading to oxidative stress. This study aims to evaluate the possibility of using of coffee and cardamom mixture, as natural antioxidant compounds, to ameliorate the damage effect of oxidative stress. Phenolic contents in coffee and essential oils in cardamom were identified by using HPLC chromatography and GC/MS analysis. Four groups of adult male rats were used; the control group (A), the second group (B) received orally mixture extract of coffee and cardamom (60 mg/100g body weight) for 8 weeks, the third group (C) γ-irradiated (6 GY) and the fourth group (D) received orally mixture extract for 8 weeks and exposed to γ-irradiation at the 4th week. The results revealed that the administration of mixture extract of coffee and cardamom were significantly reduced the damage effect induced by γ-irradiation exposure. Accordingly, it could be concluded that, via the adjustment of the antioxidant status, decreasing the releasing of lipid peroxides and the subsequent amending of different biochemical parameters and some hormones, mixture of coffee and cardamom could ameliorate the hazardous effects of oxidative stress induced by irradiation exposure.
Highlights
Ionizing radiation being used in large number of therapeutic, industrial and other applications of nuclear power generation and developing new varieties of high yielding of new crops and enhancing storage-period of food materials[1,2,3]
Due to oxidative stress induced by γ-irradiation exposure and the occurrence of different tissue damage, this study aims to evaluate ameliorating effects of coffee and cardamom mixture against biochemical changes induced by γ-irradiation
According to the method of Goupy et al [31], phenolic compounds of coffee were analyzed with high performance liquid chromatography (Hewllet Packared series 1050) equipped with autosampling injector, solvent degasser, ultraviolet (UV) detector set at 280 nm and quarter HP pump
Summary
Ionizing radiation being used in large number of therapeutic, industrial and other applications of nuclear power generation and developing new varieties of high yielding of new crops and enhancing storage-period of food materials[1,2,3]. Gamma radiation is associated with the generation of reactive oxygen species (ROS), causing oxidative damage to various tissues and induce damages in DNA and cellular membrane [3,4,5]. A number of medicinal plants evaluated for their radioprotective efficacy have shown protective effects against the damaging effects of ionizing radiation. Plant extracts eliciting radioprotective efficacy contain a plethora of compounds including antioxidants, immunostimulants, cell proliferation stimulators, anti-inflammatory and antimicrobial agents, some of which may act in isolation as well as in combination with other constituents from the same plant [6,7,8,9,10]. Habitual coffee drinking has been associated with the prevention of diseases including cancer, cardiovascular disorders, obesity and diabetes as well as neurodegenerative disorders [15,16,17,18,19,20]
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