Abstract
The controlled release of 5-fluorouracyl (5FU) and a luteinizing hormone releasing hormone analogue (LHRH) from a crosslinked bioerodible poly (ortho ester) was studied. Unlike our previous results with levonorgestrel which was released by a predominant surface erosion process, the much more water-soluble 5FU and LHRH analogue are released predominantly by diffusion. However, rate of diffusion is strongly influenced by rate of polymer hydrolysis. Because the LHRH analogue has two reactive hydroxyl groups, some are chemically bound to the crosslinked matrix via ortho ester linkages. Analysis of a model polymer matrix indicates that 95% of the LHRH analogue is released in its original form and 5% is released as the propionate ester.
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