Abstract
The aim of the study is to evaluate the use of mesoporous silicate nanoparticles for the loading and release of the non-steroidal anti-inflammatory drug, mefenamic acid. Nanoparticles of the mesoporous silicate materials, MCM-41 and SBA-16 were synthesized and characterized by XRD, SEM, FT-IR, TGA and BET surface area techniques. Both silicate systems were loaded with mefenamic acid with loading capacities of 18.6% and 11.6%, respectively. The in vitro release of mefenamic acid into simulated body fluid (pH = 7.4) at 37°C was investigated. The percent release was nonlinearly regressed against time (t) according to the first order kinetic release model; Higuchi's first burst model and Kopcha's empirical model. The overall %release was obtained for both silicate systems and was found to be about 60%. Analysis of results show the rate of drug release is more rapid from SBA-16 (the more interconnected porous network) than from MCM-41. It also show that drug release from either mesoporous silicate is a diffusion controlled process.
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