Abstract
The concentration of isosorbide dinitrate in paired samples of plasma and mixed saliva was monitored for up to 24hr after oral administration of 60mg of sustained-release isosorbide dinitrate to eight healthy volunteers. Measured isosorbide dinitrate plasma concentrations were mainly in the range of 0.1-10ng/ml. Isosorbide dinitrate was excreted into saliva resulting in a mean (±SD) saliva–plasma concentration ratio of 0.68±0.37. A significant correlation between concentrations of isosorbide dinitrate in saliva and plasma was found (p<0.01). The sustained-release properties of the administered formulation were confirmed from the concentrations of isosorbide dinitrate found in both saliva and plasma. Saliva-plasma ratios were independent of the absolute concentrations of isosorbide dinitrate but showed a slight tendency to decrease with time. The principal factor relating saliva and plasma isosorbide dinitrate concentrations appeared to be the degree of plasma protein binding of the drug.
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