Abstract
AbstractMorbidity and mortality due to postoperative complications, related to inflammation and systemic oxidative stress, of coronary artery bypass grafting is high and inadmissible. It is suggested that numerous adverse outcomes may be caused by the systemic effect of cardiopulmonary bypass (CPB). One of the most damaging consequences of these events is the formation of reactive oxygen species (ROS) and radicals, which originate from a variety of cellular and enzymatic sources, such as myocardial cells, activated neutrophils, or endothelial xanthine oxidase. Many studies have described the nature of these ROS and the time of their formation during CPB. With the goal of reducing these damages, studies have investigated the use of antioxidant supplements during CPB. The present study focused on the time course of the innate antioxidant activity (antioxidant enzymes and overall antioxidant capacity in plasma) in patients undergoing CABG. The methodology used was the literature review.
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