Abstract

1. Peptides from normal human urine (molecular weights above 500; 1000 and 10,000 daltons) inhibit the proliferation of human fibroblast cells in culture. 2. This inhibition appears both in the presence and absence of calf serum in cultures and is dosedependent. 3. The fraction of proteins having molecular weights above 10,000 daltons is the most potent inhibitor but seems to be non-toxic for the cells.

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