Abstract
Background: Acute kidney injury (AKI) is common in neonates. However, early diagnosis is difficult. Different biomarkers for early diagnosis of AKI, such as NGAL, KIM-1, Cys-C, IL-18, β2-microglobulin have been proposed. But regarding premature infant, there is very little research that has been reported. Objectives: To investigate the role of urinary NGAL and Kim-1 biomarkers for early diagnosis of AKI in premature neonates. Methods: Eighty cases were divided into experimental group (60 cases) and controls group (20 cases). Of 60 cases, 24 patients met the criteria for AKI group; the remaining 36 were non-AKI group. Blood and urine samples, 1 ml each, were collected from all subjects at first day, second day, third day and seventh day of life. Urine NGAL and KIM-1 were measured by ELISA. Results: The urinary NGAL and KIM-1 are significantly higher in AKI group than Non-AKI group and normal control group in the first three days. They present earlier than classical Scr. Conclusion: Urinay NGAL and Kim-1 are beneficial biomarkers for the early diagnosis of AKI in preterm neonates.
Highlights
Acute Kidney Injury (AKI), formerly known as Acute Renal Failure (ARF), is one of the numbers of conditions that affect kidney function and structure
We investigate the role of urinary NGAL and Kim-1 biomarkers for early diagnosis of Acute kidney injury (AKI) in premature neonates
The present study showed that the urinary NGAL and KIM-1 are significantly higher in AKI group than Non-AKI group and normal control group in the first three days
Summary
Acute Kidney Injury (AKI), formerly known as Acute Renal Failure (ARF), is one of the numbers of conditions that affect kidney function and structure. (SCr) and urine output are the classical parameter used to diagnose severity and stage of AKI. Different biomarkers for early diagnosis of AKI, such as NGAL, KIM-1, Cys-C, IL-18, β2-microglobulin have been proposed. Objectives: To investigate the role of urinary NGAL and Kim-1 biomarkers for early diagnosis of AKI in premature neonates. Results: The urinary NGAL and KIM-1 are significantly higher in AKI group than Non-AKI group and normal control group in the first three days. They present earlier than classical Scr. Conclusion: Urinay NGAL and Kim-1 are beneficial biomarkers for the early diagnosis of AKI in preterm neonates
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