Urinary levels of kidney injury molecule-1 (KIM-1) and interleukin-18 (IL-18) in children and adolescents with hyperuricemia

Abstract

PurposeHyperuricemia may lead to silent tissue damage and increase the risk of some diseases, including kidney diseases. Increased serum uric acid concentration induces inflammatory pathways and promotes kidney damage. This study aimed to determine whether hyperuricemia influences the levels of urinary kidney injury markers in children and adolescents with hyperuricemia, assessed by the urinary concentrations of interleukin-18, a biomarker of inflammation, and kidney injury molecule-1 (KIM-1), a biomarker of kidney injury. Material and methodsThe study included 73 children and adolescents (32 males and 41 females) aged 2–18 years. They were divided into two groups: hyperuricemia (HU) group (n ​= ​48) and normouricemia – reference group (R) (n ​= ​25). The concentrations of urinary interleukin-18 and KIM-1 were measured using an ELISA kit and were normalized for urinary creatinine (cr.) concentration. ResultsThe median interleukin-18/cr. Levels in the HU group were significantly higher than in the R group (median, Q1-Q3) 21.83 (11.32–35.96) and 12.68 (7.11–24.04), respectively, (p ​< ​0.05). The KIM-1/cr. in the HU group and the R group were (median, Q1-Q3) 0.79 (0.45–1.03) and 0.81 (0.59–1.01), respectively, and the difference was not significant. KIM-1/cr. did not differ between the groups. Interleukin-18/cr. ratio correlated positively with serum uric acid concentration (r ​= ​0.24, p ​< ​0.05). ConclusionsInterleukin-18/cr., but not KIM-1/cr. was higher in children with hyperuricemia. Hyperuricemia results in increased IL-18 in urine, in absence of other markers of kidney injury, suggesting inflammation in the kidney. Additional studies on the adults should be done, to confirm this hypothesis.