Abstract
The aim of the present study was to compare measurements of urinary growth hormone (GH), serum insulinlike growth factor I (IGF‐I) and IGF binding protein 3 (IGFBP3) between two groups of post‐menarcheal girls, 13–18 y of age, one comprising 64 type 1 diabetic patients and the other 64 healthy girls matched for age and stage of puberty. GH was determined on two occasions in nocturnal urine samples by using a modification of an immunoradiometric method for serum. Significantly higher urinary GH concentrations but lower IGF‐I and IGFBP3 levels were found in diabetic girls than in controls (p < 0:001). A significant correlation was found between urinary GH concentrations and the daily dose of insulin (U kg −1) (r= 0:426, p= 0:003). Urinary GH concentrations were also significantly related to HbA1c (r= 0:380, p= 0:003). In conclusion, disturbances of the GH‐IGF‐I axis may be evaluated by the use of non‐invasive urinary GH measurements, which is a simple alternative to frequent sampling of serum GH. Increased GH secretion seems to be related to a great need for insulin and poor metabolic control. More knowledge about underlying causal factors in the disturbed GH‐IGF‐I axis is required.
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