Abstract
This chapter discusses experimental studies focusing on urinary gastric secretory depressants (urogastrone). Kosaka and Lim had found that extracts of intestinal mucosa inhibited secretion from the denervated gastric pouch of the dog, and to the specific chalone or inhibitory hormone to which they attributed this effect and gave the name “enterogastrone.” The resemblance of urine extracts to intestinal extracts in their effects on gastric secretion as well as the results of an experimental study led Gray and his coworkers to conclude that the urinary gastric secretory depressant represented excreted enterogastrone and, therefore, they designated the active principle in urine as “urogastrone.” Urogastrone has been found in species which are herbivorous, carnivorous, or omnivorous. In this chapter, inhibition of gastric motility and duration of secretory inhibition is discussed. Nonspecific gastric secretory depressants are described. Details of acute dog preparation test, double-histamine dog test, continuous histamine dog test, double-histamine cat test, and pylorus-ligated rat test are presented. Origin, excretion, and mechanism of action of urogastrone are also described.
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