Abstract
Five newborn infants, whose mothers had received anticonvulsant therapy throughout gestation (diphenylhydantoin and a barbiturate [4] or diphenylhydantoin alone [1]), were studied. Urinary steroids (6β‐OH‐cortisol, tetrahydrocortisone, 16α‐OH‐pregnenolone, and 16α‐OH‐dehydroepiandrosterone) and urinary 5‐parahydroxyphenyl, 5‐phenylhydantoin (HPPH, conjugated and unconjugated) were quantitatively assayed during the early neonatal period. The urinary steroid excretions were found not to be significantly different from those of normal full‐term newborn infants. Total HPPH excretion and the unconjugated/total metabolite ratios showed no correlation with urinary steroid excretion. Thus, the enhanced 6β‐hydroxylation of cortisol seen in adults after barbiturate or diphenylhydantoin was not observed in newborns exposed to these drugs in utero.
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