Abstract
<p class="Abstract">Uricosuric activity of different extracts of <em>Tinospora cordifolia</em> was studied in hyperuricemia induced in albino Wistar rat using potassium oxonate. The uric acid level in serum and urine were measured. Uricosuric activity was also evaluated using phenol red dye excretion model. Phenol red levels were measured in blood. In potassium oxonate induced hyperuricemia, probenecid, aqueous, hydro-alcoholic, dichloromethane extract and galo satwa (starch of <em>T. cordifolia</em>) significantly lowered the serum uric acid levels. All the extracts increased uric acid excretion and decreased the elevated serum uric acid levels induced due to potassium oxonate. Probenecid, aqueous extract and galo satwa significantly increased fractional excretion of uric acid and phenol red levels in blood indicating uricosuria. Polysaccharides in aqueous extract and galo satwa may be responsible for uricosuric action.</p><p class="Abstract"> </p><p class="Abstract"><strong>Video Clips</strong></p><p><a href="https://www.youtube.com/v/t7ok0iHx8pM">Preparation of extracts</a> 4 min 22 sec</p><p><a href="https://www.youtube.com/v/jUyQMEa8rBg">Prepared extracts</a> 26 sec </p><p><a href="https://www.youtube.com/v/cnxmo69V550">Potassium oxonate induced hyperurecimia</a> 1 min 46 sec</p><p><a href="https://www.youtube.com/v/A4s8bdqVrls">Injection of red phenol into tail vein</a> 52 sec</p><p><a href="https://www.youtube.com/v/aZf3jyKDMUM">Collection of blood</a> 16 sec</p><p><a href="https://www.youtube.com/v/TVbBi-B7xPk">Estimation of uric acid</a> 1 min 44 sec</p><p> </p>
Highlights
Tinospora cordifolia (Willd) Miers Ex Hook is a large, glabrous, climbing shrub indigenous to tropical Indian subcontinent and other Asian countries from family Menispermaceae
Aqueous extract and galo satwa showed the presence of polysaccharides
Uric acid levels were significantly less in galo satwa and aqueous extract treated animals as compared to dichloromethane extract and hydro-alcoholic extract treated animals (p
Summary
Tinospora cordifolia (Willd) Miers Ex Hook is a large, glabrous, climbing shrub indigenous to tropical Indian subcontinent and other Asian countries from family Menispermaceae. It is widely used especially for immunomodulatory (Desai et al, 2007), cardioprotective (Rao et al, 2005) and hepatoprotective (Adhvaryu et al, 2008) activity. Allopurinol is contraindicated in patients with compromised renal function (Perez-Ruiz et al, 2005) and frequently causes severe hypersensitivity reactions (Halevy et al, 2008). Uricosuric agents can’t be administered in patients with renal stones (PerezRuiz et al, 1999). Galo satwa is the sedimented starch of T. cordifolia, the most widely used preparation in Indian system of medicine
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