Abstract
In order to evaluate whether an active transport of urea exists across the collecting duct epithelia of rats the following experiments were performed. Under conditions, where the net transtubular transport of urea, water, and other solutes was zero, the unidirectional flux of C14-urea out of the collecting duct and the urea concentration difference between collecting duct fluid and vasa recta plasma were measured. The following results were obtained The data indicate that in normal animals the urea transport across the collecting duct wall is passive while in rats on low protein diet an active outward transport is superimposed.
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