Abstract
The uptake of activity along tibial and peroneal fibers of the sciatic nerves of normal rats was studied at periods ranging from 1 to 13 days after a single intrathecal injection of L-Lysine-C 14. The pattern of uptake was similar in tibial and peroneal fibers of 3–4 month and 7–8 month old animals. Younger animals incorporated three to four times more activity than older ones. The average specific activity of the whole nerve kept approximately constant during the duration of the experiment. A proximodistally decreasing gradient of specific activity was found as early as 24 hours and persisted at the thirteenth day. Peaks of activity appeared in the most proximal segment at days 1–3 and 7–10. Curves of the specific activity for each nerve segment are presented. The characteristics of the peaks of activity were studied in plottings of the second derivative of the activity versus nerve length and versus time. The results are briefly discussed in relation to endoneural transport mechanisms.
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