Abstract
ObjectiveThis study investigated the relationship between aortic 18F-fluoro-2-deoxy-D-glucose (18F-FDG) uptake and clinical and laboratory findings related to atherosclerosis in a general population.Methods 18F-FDG uptake in the ascending aorta was measured on the positron emission tomography/computed tomography (PET/CT) scans of 211 Japanese adults. The maximum target-to-background ratio (TBR) was compared with clinical and laboratory atherosclerosis findings.ResultsBy multivariate regression analysis adjusted for age and sex, TBR-ascending aorta (TBR-A) was significantly correlated with various clinical and laboratory parameters, such as body mass index, log visceral fat area, low-density lipoprotein cholesterol (LDL-C), log fasting immunoreactive insulin, log homeostasis model assessment of insulin resistance, log total adiponectin and log-leptin, in all subjects. Furthermore, by multivariate linear regression analysis adjusted for confounding factors, TBR-A was significantly correlated with LDL-C (β = 0.001, p = 0.03) and log-leptin (β = 0.336, p<0.01) in all subjects.ConclusionTBR-A was significantly correlated with LDL-C and log-leptin independent from confounding factors. Our results suggest that aortic 18F-FDG uptake is a good marker of atherosclerosis, even in a general population.
Highlights
Atherosclerotic diseases such as coronary heart disease and cerebrovascular disease are the leading cause of illness and death worldwide [1]
to-background ratio (TBR)-A was significantly correlated with body mass index (BMI), waist circumference, visceral fat area, diastolic Blood pressure (BP), fasting plasma glucose (FPG), TG, uric acid (UA), Cr, immunoreactive insulin (IRI), HOMAIR, high-molecular-weight adiponectin (HMW-A), total adiponectin (T-A), and high sensitive C-reactive protein (hs-CRP) in all subjects
TBR-ascending aorta (TBR-A) was significantly correlated with BMI, IRI, homeostasis model assessment of insulin resistance (HOMA-IR), and leptin in both men and women
Summary
Atherosclerotic diseases such as coronary heart disease and cerebrovascular disease are the leading cause of illness and death worldwide [1]. Atherosclerosis has been recognized as an inflammatory disease [4]. It is well known that plaque composition and biologic activity contribute significantly to the risk of vascular events [5,6]; since angiography is invasive for the evaluation of atherosclerosis, plaque inflammation and vulnerability cannot be directly observed [7]. Some studies have suggested that inflammation and dysfunction of adipose tissue in obesity may induce abnormal production of adipocytokines and result in the higher incidence of cardiovascular diseases among obese people [8]. Adipocytokines such as leptin and adiponectin play important roles in the metabolic regulation of obesity and obesity-related complications
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
