Abstract
Summary Neonatal and 3-week-old colostrum-deprived gnotobiotic pigs were given an intragastric challenge of Escherichia coli 055:85. The resulting mortality rate was 80% in neonatal pigs and 20% in 3-week-oldgnotobiotic pigs. Histological and microbiological studies of intestinal tissues from neonatal pigs revealed large numbers of E. coli traversing the intestinal epithelium. In 3-weck-old pigs mucus-bound E. coli were commonly observed clumped within the intestinal lumen, but micro-organisms were rarely detected attached to or penetrating the intestinal epithelium. Development of a local immune response early in life may contribute to the increased resistance of the 3-week-old pig.
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