Abstract
The P2X7 receptor is a member of the P2X family of adenosine triphosphate-gated ion channels. It is expressed in the central nervous system and is associated with several pathological conditions. Here, we examined the expression of P2X7 with immunohistochemistry after cryogenic injury to the rat cortex. One day after cortical cryogenic injury, P2X7 immunoreactive cells were increased in regions surrounding the cold-injured site. These P2X7 positive cells were also immunoreactive for OX42, a microglial marker, and possessed the short, thick processes that are characteristic of activated microglia. These results suggest that the increased local expression of P2X7 may be associated with microglial activation, contributing to detrimental and/or protective functions around the cold-injured site.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
