Abstract
Kinesin family member 14 (KIF14) is a member of kinesin family proteins which have been found to be dysregulated in various cancer types. However, the expression of KIF14 and its potential prognostic significance have not been investigated in cervical cancer. Real-time PCR was performed to assess the expression levels of KIF14in 47 pairs of cervical cancer tissues and their matched normal tissues from patients who had not been exposed to chemotherapy as well as tissue samples from 57 cervical cancer patients who are sensitive to paclitaxel treatment and 53 patients who are resistant. The association between KIF14 expression levels in tissue and clinicopathological features or chemosensitivity was examined. Kaplan-Meier analysis and Cox proportional hazards model were applied to assess the correlation between KIF14 expression levels and overall survival (OS) of cervical cancer patients. KIF14 expression levels were significantly increased in cervical cancer tissues compared with matched non-cancerous tissues and it was higher in tissues of patients who are chemoresistant compared with those who are chemosensitive. KIF14 expression was positively associated with high tumour stage (P=0.0044), lymph node metastasis (P=0.0034) and chemoresistance (P<0.0001). Kaplan-Meier analysis showed that high KIF14 expression levels predicted poor survival in patients with (P=0.0024) or without (P=0.0028) paclitaxel treatment. Multivariate analysis revealed that KIF14 was an independent prognostic factor for OS. Our study suggests that KIF14 may serve as a predictor of poor survival and a novel prognostic biomarker of chemoresistance to paclitaxel treatment in cervical cancer.
Highlights
Cervical cancer is the second most common gynaecological malignancy after breast cancer in the world and is the major cause of death from gynaecological cancers in developing countries like India [1,2,3]
As shown in Figure 1(A), significantly higher levels of Kinesin family member 14 (KIF14) were detected in tumour tissues compared with non-tumour adjacent tissue (NAT) (P < 0.0001)
KIF14 expression levels were measured in tissue samples from a different population of participants consisting of 56 cervical cancer patients who are sensitive to paclitaxel treatment and 53 patients who are resistant to paclitaxel treatment
Summary
Cervical cancer is the second most common gynaecological malignancy after breast cancer in the world and is the major cause of death from gynaecological cancers in developing countries like India [1,2,3]. It is estimated that approximately 12900 new cases of invasive cervical cancer will be diagnosed and 4100 women will die from cervical cancer in the year 2015. It develops in a stepwise manner and involves a sequential progression from normal cervical epithelium to preneoplastic cervical intraepithelial neoplasia and to invasive cervical cancer [4]. KIFs are implicated in a variety of c 2016 Authors.
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