Abstract
OBJECTIVE: The nuclear Pregnane X receptor (PXR; NR1I2) is an important component of the body's adaptive defense mechanism against toxic substances including foreign chemicals (xenobiotics). PXR stimulate CYP3A4 and MDR1 gene expression in the mouse liver. Here we investigate the expression of chemoresistance (PXR and MDR1) and antioxidants (CYP3A4 and NOQ1) genes in mural and granulosa cells from patients undergoing IVF as well as in human ovarian tissues.
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