Abstract
AbstractNumerous xenobiotic-metabolizing enzymes are present in nasal tissues but little is known about the extent to which inspired vapors are metabolized in that site. In the current study, the metabolism of inspired isoamyl alcohol (an alcohol dehydrogenase substrate), and o-xylene, bromobenzene, and ferrocene (mixed function oxidase [MFO] substrates) was examined by quantitating the effects of metabolic inhibitor pretreatment on uptake of these vapors in the surgically isolated upper respiratory tract (URT) of the F344 rat and Syrian hamster under defined airflow conditions. Constant velocity unidirectional inspiratory flow rates of 35, 70, or 200 ml/min, and 50, 100, and 300 ml/min were used in the hamster and rat, respectively. In both species, URT deposition efficiency of isoamyl alcohol vapor was reduced by 3–6% by pretreatment with the alcohol dehydrogenase inhibitor 4-methylpyrazole (p <.01), providing strong evidence that this vapor was metabolized by nasal alcohol dehydrogenase. Pretreatment w...
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
