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Upper bounds for statistical uncertainties from normalization terms in neutron-scattering data-reduction

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Abstract
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We have previously reported on a systematic underestimation of uncertainties by the error-propagation mechanism in neutron-scattering data-reduction software. The problem arises in one-to-many operations that apply a single term across multiple data points, such as normalization of detector counts to a neutron monitor spectrum. While we were able to compute the correct uncertainties for a number of concrete data-reduction workflows, the solution was not necessarily generalizable and could not be applied in interactive data analysis with an a priori unknown data-reduction workflow. In this contribution, we derive upper bounds for the correct uncertainties in workflows involving such one-to-many operations. The bounds are simple and fast to compute and can be applied on the fly during data-reduction.

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The vision and mission of the Regional Head is one of the keys to the success of development in this city. One aspect that is of concern to the government is education as a form of human resource development. Zoning has an impact on the affordability of students to schools, especially public schools. This indirectly affects the capacity of the school. This study aims to determine the urgency of developing junior high school (called SMP) infrastructure with state status in the agenda setting stage. This research using mixed methods and interactive model data analysis. Interactive data analysis are popularized by Miles, Huberman and Saldana (2014), the result is that the infrastructure development of public junior high schools is needed, especially in areas affected by zone-political.

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The interactive visual analysis of set-typed data, i.e., data with attributes that are of type set, is a rewarding area of research and applications. Valuable prior work has contributed solutions that enable the study of such data with individual set-typed dimensions. In this paper, we present CrossSet, a novel method for the joint study of two set-typed dimensions and their interplay. Based on a task analysis, we describe a new, multi-scale approach to the interactive visual exploration and analysis of such data. Two set-typed data dimensions are jointly visualized using a hierarchical matrix layout, enabling the analysis of the interactions between two set-typed attributes at several levels, in addition to the analysis of individual such dimensions. CrossSet is anchored at a compact, large-scale overview that is complemented by drill-down opportunities to study the relations between and within the set-typed dimensions, enabling an interactive visual multi-scale exploration and analysis of bivariate set-typed data. Such an interactive approach makes it possible to study single set-typed dimensions in detail, to gain an overview of the interaction and association between two such dimensions, to refine one of the dimensions to gain additional details at several levels, and to drill down to the specific interactions of individual set-elements from the set-typed dimensions. To demonstrate the effectiveness and efficiency of CrossSet, we have evaluated the new method in the context of several application scenarios.

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High-throughput quantitative genetic interaction (GI) measurements provide detailed information regarding the structure of the underlying biological pathways by reporting on functional dependencies between genes. However, the analytical tools for fully exploiting such information lag behind the ability to collect these data. We present a novel Bayesian learning method that uses quantitative phenotypes of double knockout organisms to automatically reconstruct detailed pathway structures. We applied our method to a recent data set that measures GIs for endoplasmic reticulum (ER) genes, using the unfolded protein response as a quantitative phenotype. The results provided reconstructions of known functional pathways including N-linked glycosylation and ER-associated protein degradation. It also contained novel relationships, such as the placement of SGT2 in the tail-anchored biogenesis pathway, a finding that we experimentally validated. Our approach should be readily applicable to the next generation of quantitative GI data sets, as assays become available for additional phenotypes and eventually higher-level organisms.

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  • Research Article
  • Cite Count Icon 31
  • 10.1186/1471-2105-7-195
A database and tool, IM Browser, for exploring and integrating emerging gene and protein interaction data for Drosophila
  • Apr 7, 2006
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  • Svetlana Pacifico + 5 more

BackgroundBiological processes are mediated by networks of interacting genes and proteins. Efforts to map and understand these networks are resulting in the proliferation of interaction data derived from both experimental and computational techniques for a number of organisms. The volume of this data combined with the variety of specific forms it can take has created a need for comprehensive databases that include all of the available data sets, and for exploration tools to facilitate data integration and analysis. One powerful paradigm for the navigation and analysis of interaction data is an interaction graph or map that represents proteins or genes as nodes linked by interactions. Several programs have been developed for graphical representation and analysis of interaction data, yet there remains a need for alternative programs that can provide casual users with rapid easy access to many existing and emerging data sets.DescriptionHere we describe a comprehensive database of Drosophila gene and protein interactions collected from a variety of sources, including low and high throughput screens, genetic interactions, and computational predictions. We also present a program for exploring multiple interaction data sets and for combining data from different sources. The program, referred to as the Interaction Map (IM) Browser, is a web-based application for searching and visualizing interaction data stored in a relational database system. Use of the application requires no downloads and minimal user configuration or training, thereby enabling rapid initial access to interaction data. IM Browser was designed to readily accommodate and integrate new types of interaction data as it becomes available. Moreover, all information associated with interaction measurements or predictions and the genes or proteins involved are accessible to the user. This allows combined searches and analyses based on either common or technique-specific attributes. The data can be visualized as an editable graph and all or part of the data can be downloaded for further analysis with other tools for specific applications. The database is available at ConclusionThe Drosophila Interactions Database described here places a variety of disparate data into one easily accessible location. The database has a simple structure that maintains all relevant information about how each interaction was determined. The IM Browser provides easy, complete access to this database and could readily be used to publish other sets of interaction data. By providing access to all of the available information from a variety of data types, the program will also facilitate advanced computational analyses.

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  • Book Chapter
  • Cite Count Icon 7
  • 10.1007/978-3-319-66808-6_14
Quantitative Externalization of Visual Data Analysis Results Using Local Regression Models
  • Jan 1, 2017
  • Krešimir Matković + 3 more

Both interactive visualization and computational analysis methods are useful for data studies and an integration of both approaches is promising to successfully combine the benefits of both methodologies. In interactive data exploration and analysis workflows, we need successful means to quantitatively externalize results from data studies, amounting to a particular challenge for the usually qualitative visual data analysis. In this paper, we propose a hybrid approach in order to quantitatively externalize valuable findings from interactive visual data exploration and analysis, based on local linear regression models. The models are built on user-selected subsets of the data, and we provide a way of keeping track of these models and comparing them. As an additional benefit, we also provide the user with the numeric model coefficients. Once the models are available, they can be used in subsequent steps of the workflow. A model-based optimization can then be performed, for example, or more complex models can be reconstructed using an inversion of the local models. We study two datasets to exemplify the proposed approach, a meteorological data set for illustration purposes and a simulation ensemble from the automotive industry as an actual case study.

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Rosetta: A container-centric science platform for resource-intensive, interactive data analysis
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Rosetta is a science platform for resource-intensive, interactive data analysis which runs user tasks as software containers. It is built on top of a novel architecture based on framing user tasks as microservices – independent and self-contained units – which allows to fully support custom and user-defined software packages, libraries and environments. These include complete remote desktop and GUI applications, besides common analysis environments as the Jupyter Notebooks. Rosetta relies on Open Container Initiative containers, which allow for safe, effective and reproducible code execution; can use a number of container engines and runtimes; and seamlessly supports several workload management systems, thus enabling containerized workloads on a wide range of computing resources. Although developed in the astronomy and astrophysics space, Rosetta can virtually support any science and technology domain where resource-intensive, interactive data analysis is required.

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Introduction to the special issue on interactive graphical data analysis: What is interaction ?
  • Mar 1, 1999
  • Computational Statistics
  • Deborah F Swayne + 1 more

In this introduction to the special issue of Computational Statistics on interactive graphical data analysis, we first briefly introduce the papers. They cover a lot of ground, from the updating of older statistical environments to the assessment of some of the newest, and there are several interesting examples of interactive graphics applied to data analysis problems. Afterwards, we describe a questionnaire we circulated in an effort to learn about the application of interactive graphical methods to data analysis in practice. We received too few responses to find the answers to our questions, but we did observe a few interesting things. In particular, we realized that conflicting uses of the term “interactive” are currently in use, muddying our discussions of software design and data analysis practice. We’ll discuss our observations in terms of the papers in this issue. We invite you to visit http://comst.wiwi.hu-berlin.de/issue0199.html for links to color versions of many of the graphics in the papers in this issue, as well as additional graphics provided by the authors.

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