Abstract
The p53 tumor suppressor pathway plays an important role in gastric cancer (GC) development. Auto-regulatory feedback control of p53 expression is critical to maintaining proper tumor suppressor function. So far, several studies between p53 Arg72Pro polymorphism and GC have generated controversial and inconclusive results. To better assess the purported relationship, we performed a meta-analysis of 19 publications. Eligible studies were identified by searching the Pubmed database. Odds ratios (ORs) with 95% confidence intervals (CIs) were estimated to assess any link. Overall, a significant association was detected between the p53 Arg72Pro polymorphism and GC risk (Pro-allele vs. Arg-allele: OR=1.05, 95%CI=1.01-1.08; Pro/Pro vs. Arg/Arg: OR=1.13, 95%CI=1.04-1.22). Moreover, on stratified analysis by race, significantly increased risk was found for Asian populations (Pro-allele vs. Arg-allele: OR=1.06, 95%CI=1.02-1.10; Pro/Pro vs. Arg/Arg: OR=1.16, 95%CI=1.07-1.26; Pro/Pro+Pro/Arg vs. Arg/Arg: OR=1.58, 95%CI=1.09-2.27). Our study provided evidence that the p53 72Pro allele may increase GC risk in Asians. Future studies with larger sample size are warranted to further confirm this association in more detail.
Highlights
A 2005 analysis of the worldwide incidence of and mortality from cancer showed that 934,000 cases of gastric cancer (GC) occurred in 2002 and that 700,000 patients die annually of this disease (Parkin et al, 2002)
Overall, a significant association was detected between the p53 Arg72Pro polymorphism and GC risk (Pro-allele vs. Arg-allele: Odds ratios (ORs) = 1.05, 95%confidence intervals (CIs) = 1.01-1.08; Pro/Pro vs. Arg/Arg: OR = 1.13, 95%CI = 1.04-1.22)
Apoptosis is regulated by a variety of genes, including p53, which may play an important role to keep the homeostasis of the tissue dynamics (Etienne et al, 2002)
Summary
A 2005 analysis of the worldwide incidence of and mortality from cancer showed that 934,000 cases of gastric cancer (GC) occurred in 2002 and that 700,000 patients die annually of this disease (Parkin et al, 2002). Results: Overall, a significant association was detected between the p53 Arg72Pro polymorphism and GC risk (Pro-allele vs Arg-allele: OR = 1.05, 95%CI = 1.01-1.08; Pro/Pro vs Arg/Arg: OR = 1.13, 95%CI = 1.04-1.22). On stratified analysis by race, significantly increased risk was found for Asian populations (Pro-allele vs Arg-allele: OR = 1.06, 95%CI = 1.02-1.10; Pro/Pro vs Arg/Arg: OR = 1.16, 95%CI = 1.07-1.26; Pro/Pro+Pro/Arg vs Arg/Arg: OR = 1.58, 95%CI = 1.09-2.27).
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