Abstract
Unripe pear fruit extract induces the transcriptional activity of sirtuin-related genes to extend the chronological lifespan of Saccharomyces cerevisiae
Highlights
Global demographics are rapidly changing, whereby the proportion of the older population is growing at an unprecedented rate
The underlying mechanism was explored through the analysis of the expression of silent information regulator genes by reverse transcription-polymerase chain reaction, which demonstrated that the expression levels of sirtuin family genes-known regulators of the aging process-were significantly increased upon treatment with unripe pear fruit extract (P < 0.05)
These results suggest that unripe pear fruit extract might contribute to anti-aging effects in mammalian cells in vivo, supporting further exploration of the benefits of a human homolog corresponding to the aging regulator gene of yeast
Summary
Global demographics are rapidly changing, whereby the proportion of the older population is growing at an unprecedented rate. Appropriate intervention of the cellular senescence process may help to reduce the incidence and slow the progression of these aging-related diseases, while contributing to the longevity and quality of human life. The chronological aging of yeast is a complementary model to a replicative model, which simulates the cellular aging of non-dividing, albeit metabolically active, mammalian cells such as those of the brain and heart (Longo et al, 2012; MacLean et al, 2001). Because S. cerevisiae is a simple model system that can provide significant insights into the human genetics and molecular biology of senescence, it is considered to be a suitable cellular model for research on mammalian cells
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