Abstract
(±)-Hypersines A–C (1–3), the three pairs of enantiomerically pure monoterpenoid polyprenylated acylphloroglucinols with an unprecedented 6/6/5/4 fused ring system, were isolated from Hypericum elodeoides. Their structures, including absolute configurations, were elucidated by comprehensive spectroscopic data, single-crystal X-ray diffraction, and quantum chemical calculations. The plausible, biosynthetic pathway of 1–3 was proposed. Moreover, the bioactivity evaluation indicated that 1a might be a novel DNA damage response inhibitor, and could enhance MCF-7 cell sensitivity to the anticancer agent, camptothecin.
Highlights
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More than 800 PPAPs have been reported as isolated from the plants of the Guttiferae family, especially the genera Hypericum and Garcinia [2,3,4]
The results showed that none of the compounds could suppress the proliferproliferation of MCF-7 cells in 20 μM (Figure 6A)
Summary
Publisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations. Polycyclic polyprenylated acylphloroglucinols (PPAPs) have been a research hotspot among the chemical community due to their fascinating structures and diversiform pharmacological activities [1]. More than 800 PPAPs have been reported as isolated from the plants of the Guttiferae family, especially the genera Hypericum and Garcinia [2,3,4]
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