Abstract
The obesity paradox refers to the correlation between obesity and improved oncological outcomes in patients with advanced cancer, despite the fact that metabolically healthy obese individuals have an increased risk of developing cancer in the first place. In The Lancet Oncology, Alejandro Sanchez and colleagues 1 Sanchez A Furberg H Kuo F et al. Transcriptomic signatures related to the obesity paradox in patients with clear cell renal cell carcinoma: a cohort study. Lancet Oncol. 2019; (published online Dec 20)https://doi.org/10.1016/S1470-2045(19)30797-1 Summary Full Text Full Text PDF PubMed Scopus (81) Google Scholar investigated the transcriptomic profile of tumours within the context of the obesity paradox in patients with clear cell renal cell carcinoma (RCC). They investigated the angiogenic and immunological transcriptomic profiles of tumours and perinephric adipose tissue in patients with a normal weight (ie, with a body-mass index [BMI] 18·5–24·9 kg/m2, as per WHO's BMI categories) and in obese patients (BMI ≥30 kg/m2) in five cohorts of patients with clear cell RCC. Transcriptomic signatures related to the obesity paradox in patients with clear cell renal cell carcinoma: a cohort studyWe found aspects of the tumour microenvironment that vary by BMI in the tumour and peritumoral adipose tissue, which might contribute to the apparent survival advantage in obese patients with clear cell RCC compared with patients at a normal weight. The complex interplay between the clear cell RCC tumour and peritumoral adipose tissue microenvironment might have clinical relevance and warrants further investigation. Full-Text PDF
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