Abstract
New thermodynamic correlations were proposed for the solubility of pharmaceutical compounds in supercritical carbon dioxide based on the solid-liquid equilibrium model. The activity coefficient models proposed in the study were based on Universal quasi-chemical Functional Group Activity Coefficient and Wilson models. The pharmaceutical drug compounds used in this study belong to anticancer, antibiotics, anti-androgenic, non-steroidal anti-inflammatory drugs, anti-prostatic tumour drugs and antiemetic drugs. The correlating ability of the proposed models was discussed in terms of various statistical parameters. Further, the proposed model results were compared with six existing solid-fluid equilibrium model results. It was found that the newly proposed models were more promising than those of existing solid-fluid equilibrium models. The correlating ability of the proposed models was discussed in terms of various statistical parameters.
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